PRP_Components PRP_Components PRP_Components PRP_Components PRP_Components PRP_Components
PRP Components:


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Knoxville TN 37922
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Components of Platelet Rich Plasma that are injected into injury sites to speed and improve healing and reduce pain.

Growth factors are biologically active polypeptide molecules. They interact with specific cell surface receptors leading to responses that are dictated by the receptor mediated signal transduction pathways of the target cells. Growth factors are unique in that they stimulate the growth or proliferation of these target cells. Along with stimulating proliferation, growth factors cause a number of other biological processes to occur.

Platelet Rich Plasma (PRP) Injection Procedure

In this procedure, the patient's own blood is drawn and spun down (via a centrifuge in our office) and PRP is obtained from that blood sample.  Thus, the procedure uses the patient's own platelets for injection, so there is no risk of allergic reaction or contamination from other peoples' blood.  We are injecting a highly concentrated form of the patient's own platelets and their growth factors and stem cells directly into the injured or painful area in order to enhance healing and tissue regeneration.  This procedure, which takes about 1-2 hours, has become one of the mainstays of the new field of Regenerative Medicine.  Instead of just numbing an area or dampening its' inflammation, we are now able to enhance the tissue healing process itself and directly regenerate the tissues causing dysfunction and pain. 

Growth Factor Components of PRP

PDGF (Platelet derived growth factor)

TGF-αβ (Transforming growth factor alpha & beta)

EGF (Epidermal growth factor)

FGF (Fibroblast growth factor)

IGF (Insulin growth factor)

PDEGF (platelet derived epidermal growth factor)

PDAF (platelet derived angiogenesis factor)

IL-8 (Interleuking-8)

TNF-α (Tumor necrosis factor alpha)

CTGR (Connective tissue growth factor)

GM-CSF (Granulocyte macrophage colony stimulating factor)

KGF (Keratinocyte growth factor)

High concentration of leukocytes (neutrophils, eosinophils) for microbicidal events

High concentration of wound macrophages and other phagocytic cells, for biological debridement

Histamines, Serotonin, ADP, Thromboxane A2, and other vasoactive and chemotactic agents

High platelet concentration and native fibrinogen concentration for improved hemostasis

Key Cellular Components of PRP Platelets

Neutrophil (PMN) - 40-75% of circulating leukocytes

Monocyte macrophage - 2-10% of circulating leukocytes. Highly motile and migrate to soft tissues

Fibroblast - produce collagen, reticular fibers, glycosaminoglycans, glycoprotein

Endothelial Cell - permeability barrier, regulate blood flow and vascular reactivity, vasodilators, vasoconstrictors, regulate inflammation and immunity

Keratinocyte - Stratified, squamous epithelial cells Primary function is to act as a barrier

By concentrating these growth factors and injecting them at the site of injury, the body's own stem cells are drawn to the injured area and differentiate to form new healthy and robust regeneration of damaged ligaments and tendons.



 

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